Decreased red blood cell aggregation and improved deformability observed in our trial support capillary flow, especially in patients suffering from ischemic heart kinase inhibitors disease. In the background of increased deformability we could assume recently published data, which have stated that aerobic training with low lactate levels could enhance RBC deformability, which together with an increased Hct/WBV ratio indicate a better RBC oxygen transport effectiveness leads to a better oxygen supply of the myocardiocytes, and the working muscles. According to a lately observed phenomenon, cerebral and muscle tissue oxygenation indicis measured by NIRS are positively correlated with Hct/WBV ratio in sickle-cell patients comparing to healthy volunteers, which could also support our findings. Thus, our results may suggest that cardiac patients could achieve a condition of “hemorheological fitness” characterized by improved tissue perfusion, better oxygen delivery and lower vascular resistance by participating in a physical training program for 24 weeks. Furthermore, all hemorheological alterations may also contribute to the better exercise tolerability proved by the treadmill test parameter MET and the treadmill time. Moreover, the multivariate linear regression analyses showed that changes in red blood cell deformability, aggregation and WBV are independent predictors of the positive changes in MET. These results are in accordance with the above mentioned findings about improving RBC deformability and Hct/WBV ratio since they have a pivotal role in the enhancement of capillary blood flow, as well as in the oxygen supply of the myocardiocytes and the working muscles during exercise. Beneath better physical tolerance, the improvement of MET by 1 value could reduce the risk of all-cause and CV mortality by 13% and 15%, respectively. Of the clinical chemistry indicators, uric acid, triglyceride, hsCRP and fibrinogen underwent significant decreases during our study. Although we are aware that these biomarkers are considered to display only low specificity in a CV risk assessment and are easily influenced by common inflammatory diseases, our data suggest that regular long-term physical activity might exert a favorable effect on the inflammation status of patients with CAD. Further overproduction of proinflammatory cytokines such as IL-6 or TNF-a could be a marker of chronic inflammation leading to provoked and accelerated atherosclerosis, with a higher risk of CV events and mortality. Our data demonstrated an almost significant decreases in IL-6 and TNF-a levels, suggesting that a longer training program might be required to achieve significant reductions in these parameters. Interestingly, no significant change was observed in the fasting glucose.