Compared with radiotherapy alone, concomitant chemoradiotherapy represents one of the most recent advances in the treatment of NPC patients and improved the treatment outcome of patients with NPC. Our results showed that positive Reversine expression of p-Mnk1 and p-eIF4E protein, cervical lymph node metastasis, clinical stages, and combination of radiotherapy and chemotherapy were also significantly correlated with overall survival rates of NPC patients by univariate analysis. Multivariate analysis proved that the pMnk1 and p-eIF4E positive expression were the independent factors of prognosis for NPC exclude different therapy strategy, clinical stages and cervical lymph node metastasis. Therefore, over-expression of p-Mnk1 and p-eIF4E acts as novel prognostic molecular markers for NPC. In summary, we have examined the expression of p-Mnk1 and p-eIF4E in NPC and in the non-cancerous nasopharyngeal epithelial specimens, and we further compared their expression between the matched primary and metastatic or relapsed NPC tissues. By analyzing the association of p-Mnk1 and p-eIF4E and clinicopathological characteristics of NPC, we first report that the high expression of p-Mnk1 and p-eIF4E is associated with cervical lymph node metastasis and the poor survival of NPC. The p-Mnk1 and p-eIF4E might be independent prognostic factors of NPC and therefore important therapeutic targets for developing the effective treatment strategies for NPC. Left ventricular diastolic dysfunction accounts for almost half of the cases of heart failure in clinical practice. It is characterized by abnormal left ventricle relaxation or reduced ventricular compliance, which leads to increased filling pressures. Treatments for LVDD are currently limited to diuretics for symptom relief and to those addressing the underlying cause, including arterial hypertension, myocardial ischemia and aortic valve stenosis. Many studies have demonstrated the association of hypercholesterolemia with atherosclerosis and plaque formation. However, few studies reported the impairment of cardiac function in humans and animals after exposure to a hypercholesterolemic diet. To understand the genetic and molecular mechanisms underlying the cardiac impairments observed in LVDD, numerous studies assessed the expression of genes that might be related to this pathology. The level of brain natriuretic peptide, a neurohormone secreted by the ventricle in response to ventricular volume expansion and increased LV filling pressure, has been shown to be increased in patients with LVDD and animal models with accompanying LV hypertrophy. Serum BNP levels have indeed been proposed as a biomarker of LVDD severity and a link between LVDD and LV Bnp mRNA expression has been established. Oxidative stress and inflammation processes have also been reported to contribute to DD development.