The aim of the present investigation was, once again, to search for correlations between the magnitude of coronary artery disease, as assessed by angiography, and a number of systemic parameters: age, plasma calcium, phosphorus, magnesium, glucose, high density cholesterol, low density cholesterol, triglycerides, uric acid, estimated glomerular filtration rate and body mass index. A possible interaction between lipid metabolism, calcium/ phosphorus metabolism, magnesium, fasting plasma glucose, uric acid,Wortmannin renal dysfunction and excessive weight, on the one hand, and the magnitude of coronary artery lesions, and therefore mecha-nisms underlying lesion growth, on the other hand, was sought. Coronary artery atherosclerotic lesions frequently involve the deposition of lipids and of calcium. Factors such as obesity, diabetes mellitus and renal dysfunction may also play a role in coronary atherosclerosis. In the present investigation, standard coronary angiography was used as a means to estimate coronary artery disease burden, by adding the values corresponding to each lesion found. Age, uric acid and fasting plasma glucose were noted to be significantly correlated to CADB in univariate analysis. Linear regression analysis, however, only showed one of these parameters to be associated to CADB, the same happening with sex. All patients under study in the present investigation had coronary artery disease,WY 14643 and therefore no evaluation of the risk of acquiring the disease was carried out, although some of the parameters under study do act as risk factors. The present data may be of relevance in what concerns mechanisms favouring the growth of atherosclerosis lesions, since the parameter under evaluation aimed at assessing the magnitude of the total burden of disease. Lipids accumulate in arterial walls in atherosclerosis. In the present study, we could find no evidence of an association between lipid fractions and CADB. Most patients were treated with lipid-lowering drugs, and this may be one of the reasons behind these negative findings, particularly in what concerns LDL cholesterol.