Moreover, there is a need to examine the link between behavioral performance during a challenging cognitive or emotion-processing task, and brainrelated activation, to more conclusively determine whether differential brain processing patterns directly relate to measurable behavioral performance differences. Nevertheless, this study shows that with a relatively small group of subjects one can begin to delineate the neural circuitry that contributes to performance differences. The ultimate goal of these studies is to better understand the role of these circuits in determining performance, and then to develop more targeted training interventions that will Phellodendrine further improve individual and team performance in extreme and complex environments. Numerous studies have been conducted to explore the association of this ApoE polymorphism and CHD; some of the studies found a significant association between the ApoE e4 allele and CHD. A meta-analysis conducted in 2004 provided evidence that the e4 allele of ApoE was a risk factor for the development of CHD. Another meta- analysis conducted in 2013 further confirmed this finding in a Chinese population. However, no meta-analysis has been conducted to explore the association between this ApoE gene polymorphism and MI. In spite of the presence of advanced CHD, only a subset of patients develops MI during their life. The reasons for these individual differences in susceptibility to MI are poorly understood. Therefore, it is important to explore the association between ApoE gene polymorphisms and MI. In fact, a number of casecontrol studies have been conducted to clarify the association between ApoE gene polymorphisms and MI ; however, the results are inconsistent. Therefore, we conducted this metaanalysis including all of the evidence produced to date to explore this issue. Therefore, further studies are warranted among Asian populations. In addition, genotype distributions in the controls from Scaglione��s study, Bustan��s study and Zende��s study were not in agreement with HWE, therefore, the results may be biased. However, sensitivity analysis Tangeretin suggested that the pooled results were not significantly changed after excluding the three studies.