To be able to search across chemical species databases, we needed to derive the chemical formulae of the acidic termini of both TcP0 and TcP2b. The Expasy software Protparam was used to achieve this. Briefly, Protparam is a proprietary computational software available at Swiss Prot/UniProt that can be used to derive series biophysical profiles as well as determine the amino acid composition of any protein or polypeptide of interest, provided its primary structure is known. The Software has a user interface that allows one to feed the respective peptide or polypeptide primary structure into it, hence fore computing the parameters. There is a pressing need to develop new ways to kill harmful bacteria while Narcissoside causing minimal damage to eukaryotic cells. An important component of the innate response to invasive bacteria is the release of antimicrobial peptides that permeabilize bacterial membranes and ultimately kill the invaders. These peptides target bacterial membranes selectively relative to eukaryotic membranes. Thousands of natural AMPs are now known. Substantial effort has been devoted to development of synthetic analogues containing a-amino acid residues and/or unnatural subunits that mimic the selective antibacterial action of AMPs. Examples include discrete oligomers generated from L-a-amino acids, N-alkyl glycines, b-amino acids, or combinations of these building blocks. Many of these oligomers have been designed to adopt an amphipathic helical conformation, because this structural motif is common among natural AMPs. The synthesis of sequence-specific oligomers requires a step-bystep approach, typically involving solid-phase methods, which is time-consuming and expensive. This synthetic problem has encouraged several research groups to explore polymerizationbased methods to generate antimicrobial materials. In many cases, a pair of precursors is copolymerized, with one precursor giving rise to a hydrophobic (+)-pinoresinol-4-O-beta-D-glucopyranoside subunit and the other giving rise to a cationic subunit in the polymer chains. The resulting materials are heterogeneous, containing chains that vary in length, composition, subunit sequence and, frequently, subunit stereochemistry.