Nevertheless, this structural information provides a starting point for the successful development of FTO inhibitors that holds promise for developing therapeutic agents to treat obesity. Future studies are needed to determine how they contribute to substrate recognition by FTO. Previous study also Astragaloside-II showed that FTO was widely expressed in fetal and adult tissues, with the highest expression found in the brain tissue, which is a key controller of energy balance; thus, variation in expression may result in Quercetin carriers of the risk allele and develop obesity through excessive ingestion rather than altered energy consumption. Similar results have been reported in previous studies. Cecil and colleagues reported that the A allele of FTO rs9939609, which has been linked with obesity, was also associated with the control of food intake and food choice in children. Children carrying the A allele intake more energy-dense foods than those carried homozygote wild type, suggesting a link to a hyperphagic phenotype or a preference for energy-dense foods. No significant associations were found for rs7206790 and rs11644943 with diet preference, salt preference, and sweet preference, and no combined effects were observed for other FTO SNPs and dietary behaviors on obesity. However our results suggest that AA homozygous rs9939609 cases were more likely to choose a meat-based diet, which has a higher energy intake than either vegetable-based or balanced diets, compared with the other two genotypes. As discussed earlier, high energy intake may explain the predisposition to obesity and may occur through a meat-based diet. Although no significant associations were observed for dietary behaviors in our study, previous studies have demonstrated the significant effects on obesity. This inconsistency may be explained by the heterogeneity of study subjects and differences in the quantitative criteria of sweet foods. These results indicate that dietary behaviors play an important role in the development of obesity, and that at-risk children can reduce their risk of later obesity through healthy dietary behaviors such as eating more vegetables and having a preference for mild taste.