Regarding the genes encoding the different subunits of the proteasome complex, the injection of pMCV1.4-G860 induced the transcription of multitude of them. More evident was the up-regulation of all the analyzed genes after viral challenge in both groups of non-vaccinated individuals, whereas vaccinated fish showed only a modest up-regulation of some of these subunits at 24 h after VHSV challenge. As a consequence of the activation of ubiquitin and proteasome related genes, it was expected that VHSV infection would have induced the up-regulation of the main genes Sanggenone-C implicated in the MHC-I antigen presentation. On the other hand, turbot previously vaccinated with pMCV1.4-G860 presented only a modest induction of some of the above mentioned genes after viral challenge probably as consequence of the existence of an adaptive immune response limiting the proliferation success of the virus. The complement system and coagulation are two closely related pathways belonging to a complex inflammatory network and showing an intense interaction Kaempferol-3-O-glucorhamnoside between them. Pro-inflammatory cytokines play a central role in the coagulation and fibrinolysis pathways and, in an inverse way, the activation of the coagulation system may affect the inflammatory responses. Thus, the most up-regulated genes were Heparanase, Tetranectinlike protein, Platelet basic protein, Vitamin K-dependent protein S and Myelin-associated protein. Both coagulant and anticoagulant genes were up and down-regulated after pMCV1.4-G860 vaccine injection and, therefore, it is difficult to establish a general pattern with regard to this process.