Mechanical stress switches the tumor phenotype from being NK resistant to NK susceptible. Our findings indicate an immunologically relevant effect of mechanical stress on the tumor susceptibility to lymphocytotoxic attack. We incidentally observed that the different behaviour in MHC class I shedding between healthy and cancer cell could be correlated with their different mechanical rigidity. In fact, as well known and measured in optical stretchers, cancer cells systematically show a higher deformability under mechanical forces. The poorer rigidity of cancer cell, due to cytoskeleton reshuffling, induces a higher local membrane deformation that increases the detachment and the shedding of MHC class I. In our vision, this mechanism is responsible for the increased concentration of MHC class I in the supernatant. Several reports indicate that tumorigenesis is mainly associated with changes in the phospholipids and protein content on biological membranes. The data reported here provide further support to these observations, highlighting the distinct physical and chemical properties of cancer cell membranes compared to the normal ones and directly relate this observation with the cell immunogenicity. Moreover, it is possible to speculate that MHC class I molecules could differ for their biological properties accordingly with the chemical physical feature of the cell membrane lipid bilayers where they are expressed. We further speculate that organs such as heart, and related tissues such as muscles, that posses mechanical activity in their normal function, and could JTP-74057 generate mechanical stress, show a minor or absent presence of tumours. The inherent mechano-kinetic activity could generate a self-healing mechanism as described above. In the future we are planning to further investigate along this direction. We finally point out here that the use of ultrasound is particularly interesting for therapy treatments, due to their intrinsic macroscopic penetration depth in human and animal tissues. Pain is one of the most pervasive problems in our society and has high social and economic impacts. During inflammation, several mediators can activate and/or sensitize nociceptive fibers such as bradykinin, substance P, cytokines, prostaglandins and sympathetic amines. In addition to pain, similar mediators are involved in edema formation and leukocyte infiltration. If some mediators, particularly cytokines, reach the circulation, then they can cause fever by its actions in areas near the hypothalamus. Several analgesics are used to treat a wide range of painful and inflammatory conditions including non-steroidal anti-inflammatory drugs, glucocorticoids and opioids. Aside from these drugs, other drugs have been used for specific painful conditions. Despite the great diversity of available antiinflammatory and analgesic drugs, their side effects and the ineffectiveness of some drugs in some conditions require the continuous LY2835219 search for new drugs. The genus Sinningia belongs to the Gesneriaceae family and comprises 68 species that are distributed in South America. Many of them are found in Brazil.