Furthermore, in an experimental mouse model of AD,greater amounts of A��1�C42 and A��1�C40 are started to be secreted after a few months of age and then accumulated in Tg2576 mice than their wild type control litter mates throughout their lives. By using the Tg2576 mouse model for AD, we aimed to study the beneficial effects of antioxidants present in pomegranates, figs, or dates on a few neuro-inflammatory markers in blood plasma and brain regions. For this purpose, we specifically selected the fruits that are grown in Oman. Many studies suggest that different species from various geographical areas have diverse micronutrients and other bioactive components that may prevent or alleviate pathophysiological Reversine inquirer conditions. Our results showed significant increase in A��1�C40 and A��1�C42 levels both in the cortex and hippocampus. These results, consistent with the already published reports, suggest that the increased A��1�C40 and A��1�C42 accumulation is likely to promote oxidative stress responsible for the progression of neurodegeneration. Extended supplementation with pomegranates, figs, or dates indeed decreased the A��1�C40 and A��1�C42 levels in the brain of Tg2576 mice in comparison to control diet-fed mice. Despite being small but significant, the observed decreases are promising, when considering the dynamic nature of A�� present in plasma samples. Our previous studies demonstrated that dietary supplementation with pomegranates attenuates cognitive and behavioral deficits in a transgenic mousemodel of AD. The roles of pro-inflammatory cytokines in mediating a number of metabolic and neurological diseases are well documented. Our current results showed that the levels of pro-inflammatory cytokines, particularly IL-1��, TNF-�� and IL-6 in the brains of experimental animals increased in APPsw mice. The levels of IL-1��, TNF-�� and IL-6 in the cerebral cortex and the hippocampus were decreased in the brains of Tg2576 mice fed diets supplemented with pomegranates, figs or dates. IL-1��, a critical cytokine in the orchestration of the complex immune response to infection and injury, was originally described as a peripheral immune cell mediator. This cytokine has also been reported to be synthesized in the brain by glial cells and certain neurons; and IL-1�� receptors have been found in different regions of the brain, with the highest abundance in the hippocampus. Proinflammatory cytokines including IL-1��, TNF-�� and IL-6 have been reported to be Enzalutamide side effects significantly elevated in the cerebro-spinal fluid or plasma of AD patients.