However, previous work reports that biases between respondents and non-respondents are negligible in this cohort. We did not have other measures of CHD status to control the associations of D-dimer with SEP as well as we cannot adjust for underlying comorbidities, for example atherosclerosis. However, sensitivity analyses indicate that comorbidities such as heart or kidney diseases do not affect the associations between D-dimer and SEP in our sample. Additionally, we did not have repeated measures of D-dimer and therefore could not examine change in D-dimer with the change in SEP. Any future research on this topic should address the associations of D-dimer levels with social mobility. Finally, we did not address the issue of reverse causation, i.e. the possibility that poor sub-clinical health caused lower social class. In conclusion,AZD6244 there is an association of D-dimer and social position such that disadvantaged social class across the lifecourse is associated with raised levels of D-dimer. In multivariate analyses, the association of disadvantaged social position with D-dimer was largely explained by C-reactive protein and von Willebrand Factor in women, and additionally by smoking, physical activity and alcohol consumption in men. The association of haemostatic markers with social class may be mediated by inflammatory and other markers. Despite recent considerable medical advances, esophageal cancer remains a refractory disease with high morbidity and mortality. Essentially, esophageal cancer is the 6th leading cause of cancer-related mortality and the 8th most BAY-60-7550 common cancer worldwide. There are more than 450,000 patients diagnosed as esophageal cancer worldwide and the incidence is still rising rapidly. Meanwhile, its startling overall 5-year survival rate ranges from 15,25%. In China, more strikingly, esophageal cancer ranks the 5th most common diagnosed cancer and 4th leading cause of cancer related mortality. Esophageal squamous cell carcinoma is the predominant histological type of esophageal cancer.