The basic idea of HD culture is to maintain cell-cell interactions in culture, which is a well-known factor of the stem cell niche in situ. Theoretically, besides EPCs, other stem cells, including HSCs and MSCs from the bone marrow, might also be expanded in this culture. The higher expression levels of CD34, CD29, and CD90 supported this. The osteogenic and chondrogenic AR7 potential of HD cultured cells has been shown, while the hematogenic potential of these cells is still under investigation. HSCs and MSCs are cell types shown to possess antifibrogenic potential in liver injury. Comparing transplantation of purified cell populations, transplantation of a mix population can enhance tissue repair in many cell therapy models. This is likely because of the different role of cells in one physiological and pathological process. For example, EPCs require the presence of MSCs to enhance new blood vessel formation. Therefore, it is not surprising that an enhanced antifibrogenic effect was achieved by treatment with HD cultured cells containing mixed stem cell populations. In addition, growth factors favored for liver regeneration were highly expressed in this culture, which also supports better outcome of this treatment. Compared with the general population, individuals with chronic kidney disease are at an increased risk for cardiovascular disease and death from cardiovascular events. CVD is the Phosphatase Inhibitor Cocktail (EDTA-Free, 100X in DMSO & 100X in H2O) leading cause of mortality in individuals with varying degrees of CKD. Therefore, preventive measures for CVD are of great importance in patients with CKD. Previous studies have demonstrated that efforts to lower blood pressure and lipid levels are effective for reducing the risk of CVD in patients with CKD. However, the importance of other potential preventive therapies, such as antiplatelet agents, remains controversial.Aspirin has been shown to be effective in reducing cardiovascular morbidity and mortality in high-risk patients who have experienced myocardial infarction or stroke and is recommended as a secondary prevention strategy for individuals with multiple risk factors such as hypertension, dyslipidemia, obesity, diabetes, and a family history of ischemic heart disease.