In addition, we have shown that efficient GDP detection is not dependent on a narrow region of finely tuned parameters, but rather, can be obtained for a wide range of different parameter values, provided specific parameter relationships are maintained. Finally, we have outlined the implications that a GDP interpretation has on everything from chronic infection to allergies, and we have shown how GDP can rationalize the observed responses of the immune system to various types of pathogenic, Terutroban environmental and self antigens. The GDP model by no means lessens the importance of other, more traditional views of immune system activation. In fact, we do not expect GDP to replace immune system activation schemes involving spatial pattern recognition. Rather, we view GDP as working in parallel with these other mechanisms. For example, strong TLR stimulation will almost certainly circumvent the GDP pathway entirely, while GDP induced Treg up-regulation might quell an immune response initiated by weak TLR engagement. To that end, we note that the easiest system in which to study GDP is a setup similar to the Abbas lymphopenic mouse model, since this system eliminates many of the other mechanisms of immune regulation that may overshadow GDP itself. While we have focused on the interplay between Treg cells and Th17 cells, the immune system��s ability to monitor growth is likely far more complex and sophisticated than the simple model that we present here. Time-dependent information, for instance, will almost certainly prove to be encoded not only in the relative sizes of the Treg and Th17 cell populations, but also in the population sizes of other cell types, including Th1 and Th2 helper T cells, and possibly even APCs like dendritic cells and macrophages. Therefore, the ��activation versus suppression�� step that we have outlined in this paper is meant to be taken as a significant approximation to the real system, which likely Naringenin involves further decision-making processes made either in parallel with, or else following after the Treg/Th17 decision itself.