Due to the large proportion of sequences that map to introns in FFPE RNA-Seq data, we included reads mapped to the introns to comprehensively measure expression of each gene. In this study, we detected fusion transcripts in two breast cancer cohorts, the Providence cohort of 136 patients and the Rush cohort of 76 patients with average FFPE block archive ages of 8.5 years and 13.4 years respectively. These two cohorts have been previously used in the development of a 21-gene qRT-PCR breast cancer recurrence risk assay. Recently, the whole transcriptome RNA-Seq analysis of the Providence cohort has demonstrated that the technology used is sensitive and specific. These gene feature counts are referred to as ‘‘gene tables’’ in Figure 1A. Furthermore, oxidized LDL, which is increased in SLE patients, may also participate in the initial platelet activation. Thus, based on our results, we suggest that complement deposition is increased in SLE patients due to ongoing platelet activation and this process, both platelet activation and complement activation on platelets, is amplified in the presence of aPL antibodies. On the other hand, the Action to Control Cardiovascular Risk in Diabetes trial found that tight control of HbA1c below 6.0% increased mortality risk, and both the ACCORD trial and the Veterans Affairs Diabetes Trial did not find that tight control of HbA1c led to an additional reduction in the risk of cardiovascular disease. However, the Action in Diabetes and Vascular Disease Preterax and Diamicron Modified Release Controlled Evaluation did suggest that achievement of HbA1c below 6.5% was able to further reduce nephropathy by about 20%, which may be translated to a CVD risk reduction in the long run. Obesity, hypertension and insulin resistance often occur in clusters to increase the risk of diabetes.