How small RNAs involved in expression of efflux pumps remains to be investigated in DR1 cells. Our study will serve as a baseline for understanding the effects of antibiotics on Acinetobacter species, and it should help in developing a new strategy for predicting novel antibiotic-resistance mechanisms, as well as for preventing multidrug resistance across multiple Dibenzothiophene species of bacteria by using this soil-borne bacterium. The first committed step of heme biosynthesis in non-plant eukaryotes and some prokaryotes, the pyridoxal 59-phosphate -dependent condensation of glycine and succinyl-coME0328 enzyme A to generate 5-aminolevulinate is catalyzed by 5-aminolevulinate synthase. This reaction is directly coupled to the citric acid cycle via the substrate succinyl-CoA and is the key regulatory step of heme biosynthesis.Proteins involved with DNA repair and oxidative stress alleviation were also induced in D. radiodurans under ionizing radiation stress. Proteins involved in protein folding processes are mostly downregulated post-irradiation. This represents an unexpected result, since these proteins are classically involved with stress response by stabilizing newly synthesized protein molecules. Nevertheless, this result is in agreement with transcriptomic data observed in microarray experiments. HRMs confer heme-binding properties and have been shown to function as heme-oxygen sensors in bacteria, yeast and mammals.In in vitro translocation experiments with isolated mitochondria and ALAS2 precursor protein, the two hemebinding motifs in the leader sequence, corresponding to C11 and C38 in murine ALAS2, were reported to bind heme and prevent translocation of precursor ALAS2 into the mitochondrion.