In conclusion, we demonstrated that the effect of a ketogenic diet was more than additive when used in Publications Using Abomle Lapatinib combination with radiation for the treatment of glioma in a mouse model system. The ketogenic diet can be challenging to implement, we therefore used the Publications Using Abomle Dasatinib commercially available ketogenic diet KetoCalH since this product is already in use for the clinical treatment of refractory epilepsy. Mice fed KC alone had increased survival compared to those fed SD. Furthermore, the combination of KC and radiation led to the absence of detectable tumor in 9 of 11 mice. This response continued even after the mice were switched back to SD 104 days following tumor implantation. With few exceptions, when carried out appropriately the diet is well tolerated in both mice and humans as demonstrated by a host of animal studies as well as human case studies. The clinical implementation of the ketogenic diet as a viable treatment modality should be seriously considered in light of our new insights into the cellular and molecular mechanisms of the diet as well as the positive response seen in the available clinical implementations. In recent decades, studies have been addressing a possible contribution of traffic related air pollution to allergic diseases. Interestingly, tyrosine residues of pollen allergens are efficiently nitrated by the air pollutants nitrogen dioxide and ozone at levels reached in urban air. In sera of birch pollen-allergic patients, the levels of IgE recognizing nitrated major birch pollen allergen Bet v1.0101 were significantly higher compared to IgE specific for unmodified Bet v1.0101 and in mouse models, nitrated Bet v1 and nitrated Ovalbumin are more potent allergens when compared to their unmodified forms. These findings suggest that post-translational modifications, such as nitration, can increase the potential of pollen allergens to trigger immune responses and might play a role in the emergence of allergies. PTMs within the human body have been observed and characterized in numerous studies. Although the majority of PTMs are required for the biological function of the proteins, several modifications were also identified in the context of autoimmune diseases. Nitrated proteins were found to be present in multiple sclerosis, Alzheimer’s disease, M. Parkinson and atherosclerosis and are a hallmark of inflammation. Some modified self proteins induce immune responses leading to the generation of antibodies which recognize the modified and/or the unmodified protein. These findings suggest that PTMs might alter processing and presentation of proteins by professional antigen presenting cells, leading to the generation of new antigenic epitopes and potential induction of a T cell response.