Suggesting that repellency affects a small area around the mouse, thus interfering with mosquitoes feeding on the mouse in proximity. In the near future, we intend to further explore this and other potential applications for the system, as the use of spatial repellents has been proposed as an additional strategy for the control of arthropod-borne diseases. In fact, recent reviews focusing on the efficacy of repellents show a number of established compounds and others with great potential as well as different techniques for selecting these repellents. We present our system as an option for an initial screening using live small laboratory animals. Classic studies from over a century ago have demonstrated mosquito preference toward black or dark colors rather than light colors, although their preference for other colors is less clear. Finally, it is important to highlight the limitations and advantages of the method described here. Because of its simplicity, the method is not able to replace olfactometers, since it does not consider a number of variables that may influence mosquito attractiveness. It also relies on live blood sources, and maintaining facilities to breed, feed and raise these animals is costly. Nevertheless, despite the approval of our IACUC, and the use of an EB dose below DL50, the ethical limits of animal use on research has been challenged in several countries. In addition, it is not a useful procedure for blood meal identification because it works only with known host species. On the other hand, the method can be validated in the future to alternative FTY720 Src-bcr-Abl inhibitor sources of blood and to evaluate whether host cellular and humoral blood factors interfere with mosquito engorgement. Thus, considering all these factors, we believe that a simple and relatively cheap system that requires a small space to be operated would be of interest to entomologists and chemical ecologists and it represents an important contribution to those groups interested in aspects of mosquitoes’ blood feeding and vector-host interactions. Dynamic changes in histone acetylation patterns are mediated by the activity of histone acetyltransfereases and histone deacetylases and are key events in the epigenetic regulation of gene expression. In addition, many non-histone targets of HATs/HDACs have been described and it has been demonstrated that reversible lysine acetylation can affect proteinprotein and protein-DNA interactions, protein stability and intracellular localization. This implies that lysine acetylation is an important post-translational modification regulating a variety of cellular pathways and thus broadening the functional role of HATs/HDACs beyond epigenetic gene regulation.