Where effective risk factor management can be achieved through long-term life style changes. Impaired hemorheological parameters, including reduced erythrocyte deformability and increased erythrocyte aggregation, may have a deleterious effect on the vascular system leading to the development of various CV, cerebrovascular and peripheral arterial diseases. Whereas publications from the last 25 years have clearly revealed a relationship between hemorheological factors and physical training, those studies involved healthy volunteers or a small numbers of CV patients participating in short-term exercise training. Furthermore, the possible connections between hemorheology and long-term, moderate aerobic physical activity have not been investigated in a relatively large population with ischemic heart disease. Our study had the aim of determining the beneficial effects of aerobic physical training on ischemic heart disease patients participating in a long-term ambulatory CR program. The psychological data revealed a significant deviation from the normal distribution, and; the nonparametric Friedman test was therefore applied to analyze potential changes in psychological functioning. The analyses of the psychological data was restricted to those patients who had no missing surveys and gave no indication of moderate to severe depression at any of the three measurements. Five patients indicated moderate to severe depression during the rehabilitation period, and six of them had missing surveys. The fundamental problem of CAD patients can not be solved completely via revascularization techniques, effective and long-term lifestyle changes are at least as vital as other therapeutic procedures. Recent studies such as EuroAction and GOSPEL have indicated that regular long-term physical activity results in more benefit than short-term training programs as regards the prognosis of cardiac patients. A physical training program is strongly recommended by the ESC and the AHA/ ACC as well. Aerobic exercise training is defined as a sub-category of physical activity in which planned, structured, and repetitive bodily movements are performed to maintain or improve physical fitness. According to the recommendations of ESC guidelines regarding physical activity and CAD prevention, patients with previous acute myocardial infarction, CABG, PCI, stable angina pectoris, or stable chronic heart failure should undergo exercise training strong evidence), which should be performed at least 30 minutes long and 3–5 times weekly, in form of an aerobic exercise training evidence), at 70–85% of the peak heart rate or 40–60% of heart rate reserve or 10/20–14/20 of the Borg Scale. It is a long revealed fact that impaired hemorheological factors are CV risk factors, and the improvement of these could result in lower CV risk and BU 4061T Proteasome inhibitor mortality.